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. Author manuscript; available in PMC: 2015 Aug 11.
Published in final edited form as: Discoveries (Craiova). 2015 Mar 31;3(1):e41. doi: 10.15190/d.2015.33

Figure 1. Regulation of IL-1 signaling by native inhibitors and decoy receptors.

Figure 1

IL-1α, or IL-1β binds to IL-1R1 and forms a complex with IL-1RAcP, recruiting myeloid differentiation protein 88 (MyD88) and triggering the signaling cascade that involves IRAK-1 and IRAK-4 activation (A). The endogenous inhibitor IL-1Ra also binds to IL-1R1, but does not signal because it fails to form a complex with IL-1RAcP (B). IL-1 binding to the decoy receptor IL-1R2 does not result in stimulation of a signaling cascade, as this receptor lacks a cytoplasmic segment (C).