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. Author manuscript; available in PMC: 2015 Aug 11.
Published in final edited form as: Discoveries (Craiova). 2015 Mar 31;3(1):e41. doi: 10.15190/d.2015.33

Figure 2. The cellular targets of IL-1 in myocardial infarction.

Figure 2

IL-1α (released by necrotic cardiomyocytes) and IL-1β (newly synthesized and secreted by resident myocardial cells and infiltrating leukocytes) signal by activating IL-1R1. IL-1 induces cardiomyocyte apoptosis and suppresses cardiomyocyte function, stimulates a matrix-degrading pro-inflammatory program in cardiac fibroblasts and delays fibroblast to myofibroblast transdifferentiation, induces cytokine expression in macrophages, mediates leukocyte recruitment by inducing adhesion molecule expression by endothelial cells and prolongs neutrophil survival.