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. Author manuscript; available in PMC: 2015 Oct 21.
Published in final edited form as: Nat Commun. 2015 Sep 23;6:8250. doi: 10.1038/ncomms9250

Figure 5. Acute in vivo effect of 1 in mice in an OGTT.

Figure 5

(a) and (c): Mice (WT and Ide−/− C57BL/6J) were treated with 1 at 50 mg/kg (blue line) or with vehicle (grey line) intraperitoneally. Plasma glucose concentrations measured immediately before inhibitor injection, corresponding to t=−15 min, immediately before oral glucose challenge (3g/kg, at t=0), and up to 180 min after it. Inserts represent AUC (−15to180). (b) and (d) : Insulin concentration measured in the same animals (WT and Ide−/− C57BL/6J) (1: blue bars; vehicle: grey bars) was measured at the indicated time points. One out of three independent experiments is shown. The experiment shown was performed as “cross-over”, such that the group initially treated with vehicle was treated two days later with 1 and vice versa. Data are means ± s.e.m (n=6 mice per group). two-sided t-test * p < 0.05; ** p < 0.01 ; *** p < 0.001