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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Mol Oncol. 2015 Aug 6;10(1):1–23. doi: 10.1016/j.molonc.2015.07.005

Table I.

Summary of Pathways for rLOX-PP Uptake

MINOR PATHWAYS MAJOR PATHWAYS
Dynamin-Dependent Uptake Dynamin-Independent Macropinocytosis
Cell Line Clathrin (Dynasor e) Caveolae (Caveolin-1 siRNA) Actin (Cytochalasin D) PI3K (LY294002)
PWR-1E + + +
DU145 +++
PC3 + +++ + ++
SCC9 ++ +
MDA-MB-231 +++ ++ +

The symbols +++, ++, and + respectively indicate high-, intermediate-, or low involvement of the respective pathway. Parentheses identify the inhibitor of the pathway which provides evidence for the indicated outcome.