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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Kidney Dis (Basel). 2015 Sep 23;1(3):194–203. doi: 10.1159/000439196

Figure 1.

Figure 1

A) An integrative biological approach is necessary to understanding the basis of diabetic kidney disease. This approach combines diverse sets of sophisticated expertise in an attempt to better characterize the pathophysiology of this complex disease. B) Systems biology tools are used to describe the alterations seen in diabetic kidney disease at each point along the genome-phenome continuum. The goal is to integrate these data to visualize how alterations at specific points result in downstream events, ultimately in the diabetic kidney disease phenotype.