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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Kidney Dis (Basel). 2015 Sep 23;1(3):194–203. doi: 10.1159/000439196

Figure 2.

Figure 2

Deep phenotyping is combined with molecular analysis in an attempt to more specifically associate clinical and histopathologic specifics seen in diabetic kidney disease with resulting molecular alterations. The molecular alterations (such as transcription level of a particular gene) can then be correlated with a clinical outcome (such as GFR). This approach can be used to identify genes, molecules, and pathways that are associated with disease, which can then be validated in model systems.