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. Author manuscript; available in PMC: 2016 Sep 23.
Published in final edited form as: Arthritis Rheumatol. 2016 Jan;68(1):127–137. doi: 10.1002/art.39337

Figure 4. Pharmacologic cholesterol inhibition attenuates osteoarthritic changes in mice.

Figure 4

Representative histological sections showing haematoxylin and eosin staining of the knee joints in 4-month-old mice that were implanted with a slow release Placebo (top panels) or Statin pellet (bottom panels). Methods for inducing osteoarthritis include Hh activation (Col2a1-Gli2), cholesterol accumulation (InsigDKO), or both (Col2a1-Gli2;InsigDKO), as well as surgical excision of the medial meniscus (Surgery) in Control and InsigDKO mice. Arrows point to hypertrophic chondrocytes and cartilage fibrillation in Placebo-treated mice. Scale bar, 100 μm.