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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Am J Clin Nutr. 2008 Dec 10;89(2):525–532. doi: 10.3945/ajcn.2008.26591

Table 1.

Concentration of PF, sTfR and Hgb and red cell indices 1,2

Age 1 mo 4 mo 5.5 mo 7.5 mo 9 mo 12 mo 15 mo 18 mo
Number of Subjects Fe 31 31 31 31 30 25 25 25
Plac 32 32 32 29 29 28 27 27
PF (μg/L) Fe 279 ± 129 152 ± 82 118 ± 98 85 ± 74 57 ± 44 43 ± 34 29 ± 17 26 ± 18
Plac 316 ± 121 123 ± 80 64 ± 48 50 ± 34 43 ± 28 31 ± 18 27 ± 18 25 ± 14
p 0.0044 0.031
PF adj.3 (μg/L) Fe 294 ± 133 143 ± 71 97 ± 61 66 ± 55 44 ± 23 36 ± 18 26 ± 12 23 ± 14
Plac 298 ± 118 109 ± 62 63 ± 41 51 ± 26 45 ± 24 32 ± 20 28 ± 21 27 ± 17
p 0.038 0.009
sTfR (mg/L) Fe 3.76 ±1.34 5.65 ± 1.61 4.81 ± 1.60 5.43 ± 2.04 5.33 ±1.71 5.51 ±2.04 5.34 ± 1.90 4.69 ±1.33
Plac 3.54 ±1.10 5.74 ± 1.83 6.01 ± 1.57 5.77 ± 1.84 5.64 ±2.03 5.29 ±2.29 5.42 ± 2.15 5.50 ±1.94
p 0.005
Ln[sTfR/PF] Fe 2.68 ±0.61 3.75 ± 0.74 3.94 ± 0.95 4.32 ± 0.73 4.80 ±0.88 4.99 ±0.75 5.23 ± 0.68 5.39 ±0.66
Plac 2.49 ±0.59 4.09 ± 1.00 4.78 ± 0.96 4.88 ±0.65 5.00 ±0.75 5.20 ±0.76 5.42 ± 0.91 5.49 ±0.76
p 0.001 0.008
Hgb (g/L) Fe 132 ± 17 118 ± 7 121 ± 9 117 ± 9 116 ± 9 117 ± 10 115 ± 10 121 ± 10
Plac 127 ± 13 117 ± 7 117 ± 8 115 ± 10 115 ± 8 117 ± 7 120 ± 8 122 ± 8
p
RDW (%) Fe 15.3 ± 1.0 12.2 ± 0.8 12.6 ± 0.6 13.3 ± 0.9 13.3 ± 0.9 13.7 ± 0.8 13.7 ± 0.8 14.2 ± 1.0
Plac 15.4 ± 0.9 12.6 ± 0.9 12.9 ± 1.1 14.0 ± 1.3 14.2 ± 1.3 14.2 ± 1.2 14.3 ± 1.1 14.3 ± 1.1
p (0.055) 0.035 0.002 0.022
MCV (fL) Fe 98 ± 2 82 ± 3 79 ± 3 80 ± 3 81 ± 3 81 ± 2 80 ± 4 80 ± 4
Plac 96 ± 4 81 ± 3 78 ± 3 78 ± 3 79 ± 3 79 ± 4 80 ± 4 80 ± 4
p 0.046 0.010
1

PF= plasma concentration of ferritin, sTfR = plasma concentration of soluble transferrin receptor, Hgb = concentration of hemoglobin. Fe = iron group, Plac = placebo group. Values are means ± SD.

2

data for 63 subjects who completed intervention at 5.5 mo; data for infants who were treated for iron deficiency excluded after start of treatment

3

adjusted for current weight and PF at 1 mo (values at 1 mo adjusted only for current weight); values generated from the residuals of regression of log PF on body weight and initial PF. Residuals were added to mean log PF and ant-logarithms were used to generate adjusted PF in original units

4

values in same column differ significantly between Fe and Plac if a p-level (ANOVA, ANCOVA) is specified

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