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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Hum Brain Mapp. 2015 Jun 12;36(9):3603–3620. doi: 10.1002/hbm.22865

Figure 6.

Figure 6

Voxelwise comparison between healthy (CDR 0) and impaired (CDR 0.5) cognitive function groups from Healthy Aging and Senile Dementia (HASD) cohort using wavelet-based regularity analysis, MSE analysis, and fALFF. Results from two sample t-tests show decreased regularity in the CDR=0.5 group at scales a) D4, corresponding to the frequency range 0.028–0.014 Hz, and b) D5, corresponding to the frequency range 0.014–0.007 Hz. c) Two sample multivariate t-tests performed voxelwise across scales D2-D5 show an extended number of regions affected. d) MSE and fALFF two sample t-test (univariate) results are shown. MSE differences are observed only for s=2 and appear over a far narrower range of slices. Similarly, fALFF differences occur within a single cluster. All results are significant to p<0.005, and further cluster corrected for p<0.05, with a cluster size minimum of 60. Two resting state network masks, defined using group ICA across both groups, are shown for comparison: posterior default mode (blue), and a composite of the left and right executive control (green).