Table II.
Group differences between CDR-0 and CDR-0.5, using Wavelet-based Regularity analysis, Multiscale Entropy analysis, and Fractional Amplitude of Low Frequency Fluctuation (ALFF). Region, cluster center (MNI coordinates), and cluster size of two sample t-tests results are shown (p<0.005, cluster corrected for p<0.05).
| Location | MNI (x, y, z) | Size | MNI (x, y, z) | Size | MNI (x, y, z) | Size |
|---|---|---|---|---|---|---|
| Wavelet-based Regularity | D2-D5 | D5 | D4 | |||
| L. Fusiform | −38, −66, −12 | 490 | −36, −67, −12 | 1300 | −38, −62, −12 | 162 |
| R. Sup. Frontal | 18, 54, 33 | 215 | 18, 57, 31 | 274 | 17, 59, 32 | 179 |
| 25, 15, 59 | 66 | 27, 15, 63 | 69 | 24, 13, 65 | 61 | |
| Supp. Motor Area | 3, 12, 63 | 82 | 1, 12, 64 | 153 | −2, 10, 66 | 86 |
| −7, −12, 63 | 70 | |||||
| R. Caudate | 10, 8, 7 | 74 | ||||
| L. Thalamus | −10, −22, 1 | 61 | ||||
| L. Mid. Cingulate | −8, 4, 43 | 548 | ||||
| L. Cerebellum (crus I) | −18, −80, −24 | 140 | ||||
| R. Cerebellum (crus II) | 30, −76, −44 | 262 | 25, −81, −46 | 197 | ||
| L. Mid. Frontal | −29, 21, 37 | 172 | −24, 29, 21 | 76 | ||
| R. Mid. Frontal | 47, 25, 34 | 68 | 45, 44, 19 | 62 | ||
| L. Mid Occipital | −35, −81, 23 | 69 | −34, −84, 22 | 63 | ||
| R. Inf. Occipital | 38, −81, −13 | 130 | ||||
| R. Inf. Oper. Frontal | 41, 13, 12 | 88 | ||||
| L. Precuneus | −14, −58, 30 | 67 | ||||
| L. Sup. Frontal | −19, 7, 60 | 93 | ||||
| L. Postcentral | −42, −12, 41 | 66 | ||||
| L. Inf. Occipital | −31, −81, −11 | 219 | ||||
| Multiscale Entropy | s = 2 | |||||
| R. Insula | 40, 13, −2 | 72 | ||||
| R. Sup. Orb. Frontal | 20, 55, −6 | 101 | ||||
| L. Inf. Orb. Frontal | −37, 41, −16 | 140 | ||||
| Fractional ALFF | 0.11 – 0.01 Hz | |||||
| R. Caudate | 20, −11, 23 | 144 |