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Signature sequence for the PurM superfamily. The sequences shown are EcPurM (E. coli), TmPurL (T. maritima), AaThiL (A. aeolicus), AaSelD (A. aeolicus) and EcHypE (E. coli). The boxed regions are residues absolutely conserved throughout the superfamily. The conserved aspartic acid serves as a ligand for a magnesium ion. The lengths of the spacers vary among species and the glycine residues outside the box show some species variation but are always small residues.
