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The proposed acylphosphate intermediate in the reactions catalyzed by PurD, PurK, PurT and PurP. Nu: for PurD is the amino group of PRA, for PurK, the 5-amino group of AIR, for PurT, the amino group of GAR and for PurP, the amino group of AICAR. R5P is ribose 5′-phosphate. The amide group formed in each reaction is indicated by a dashed box.
