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. Author manuscript; available in PMC: 2016 Apr 27.
Published in final edited form as: Nat Commun. 2015 Oct 27;6:8692. doi: 10.1038/ncomms9692

Figure 4. Local TNP payload accumulation correlates with DNA damage in OVCA.

Figure 4

(a) Single-cell DNA damage response correlates with local TNP payload levels in a model of disseminated metastatic OVCA. A2780CP OVCA cells were injected intraperitoneally; 6 weeks later, TNP was i.v. injected, and the following day intraperitoneal lesions were excised and imaged for DNA damage response (using 53BP1 puncta) and TNP uptake. Scale bar = 50μm. (b) OVCA cells exhibiting detectable DNA damage by 53BP1-puncta have higher TNP payload levels, compared to those without (*two-tailed t-test; S.E.M. across n=3 animals).