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. Author manuscript; available in PMC: 2016 Apr 27.
Published in final edited form as: Nat Commun. 2015 Oct 27;6:8692. doi: 10.1038/ncomms9692

Figure 9. TNP delivery to the liver blocks development of micro-metastases.

Figure 9

(a) Representative liver micro-metastasis, 2 weeks after i.v. injection of 4T1 breast cancer cells (H&E staining of FFPE tissue section). (b) TNP reduces liver micro-metastasis development in the 4T1 model of hematogenous metastasis (*two-tailed t-test; shown as mean ± S.E.M.; n ≥ 5). To initially deliver TNPs to host phagocytes (rather than tumor cells), TNPs were i.v. administered (1 mg kg−1) 6 hr before i.v. injection of 4T1 cancer cells, such that TNP largely cleared the circulation at the time of cancer cell administration. 1/3 of the cohort received subsequent TNP treatments as indicated.