Table 3.

Outcome measures from probabilistic tractography using the right MOFC as the seed and all voxels in the brain as the target. F-test includes age, site and sex as covariates. For total number of tracts, seed size is also included as a covariate. Data are presented as mean ± standard deviation.

	HC (N=39)	MDD (N=123)*	F-test
Weighted FA	0.32 ± 0.03	0.32 ± 0.03	F(1,157)=0.32, p=0.57
Total number of tracts	2,041,410 ± 575,536	2,030,248 ± 523,381	F(1,155)=0.12, p=0.73

^*Two subjects were removed for the “Total number of tracts” analysis due to extremely high values (>7 million tracts).

Abbreviations: FA=fractional anisotropy, HC=healthy control, MDD=major depressive disorder.