IL-23 neutralizations inhibit MBP-induced EAE in B10.PL mice. EAE was induced in B10.PL mice as described in the materials and methods section, and animals were treated with PBS, negative control rat IgG, anti-IL-12/23p40, or anti-IL-23p19 mAbs at days –1, 6, and 13 (arrows). Daily clinical scores were averaged for the group and are shown through 70 d post–EAE immunization.