Table I.

Cohort Characteristics

Characteristic/Test	APOEε4 Carriers (n=34)	Non-Carriers (n=46)	P-value
Age (yr)	68.1	66.7	0.470
Sex (M/F)	16 / 18	15 / 31	0.247
Family History (Yes/No)	26 / 8	30 / 16	0.330
Education (yr)	17.0	17.2	0.593
MMSE (0–30)	28.6	28.9	0.390
Boston Naming (0–60)	56.1	56.0	0.973
WMS LM Delay Total (0–50)	23.4	28.9	0.007**
WMS VP Delay (0–10)	6.1	7.1	0.024*
Buschke CLTR (0–144)	58.2	60.9	0.742
WAIS Digit Span	18.4	17.6	0.399
WAIS Digit Symbol	64.1	63.0	0.780
Fluency: Fruits and Vegs	18.4	19.6	0.294

APOEε4 carriers and non-carriers do not significantly differ in age, sex, family history of AD or education. Measures of intelligence and cognition did not differ between groups, except on two verbal memory tests. As a result, verbal memory performance was regressed out of imaging analyses. APOEε4 = apolipoprotein E ε4 MMSE = Mini Mental State Exam; WMS = Wechsler Memory Scale; LM = Logical Memory; VP = Verbal Paired Associates; CLTR = Consistent Long-Term Retrieval; WAIS = Wechsler Adult Intelligence Scale;

^*= p<0.05;

^**= p<0.01