Table 1.

The table summarizes pertinent clinical features of six patients with OPTD.

Patient	Age/Gender	History	Nystagmus	Palate tremor	Dystonia	Other movement disorders	Pharmacothera py
1	48/F	Resection of deep cerebellar mass	Torsional and vertical nystagmus on slight left gaze, nystagmus increases with further eccentric left gaze, no nystagmus on straightahead gaze	Yes	Torticollis (mild) Right hand (mild), both feet (moderate)	Lip tremor, Speech tremor	Baclofen, Clonazepam, Botulinum toxin
2	46/M	Hemorrhagic stroke in pons and midbrain due to unknown etiology	Coarse irregular dysconjugate eye oscillatiions in horizontal, and vertical directions.	Yes	Left laterocollis (mild), right torticollis (mild), right hand	Head tremor	Memantine
3	26/M	Pliocytic astrocytoma status post radioablation, hemorrhage	Horizontal and vertical pendular nystagmus in straight-ahead and eccentric gaze	No	Low face dystonia	Upper extremity ataxia	Leviteracetam (for history of seizure)
4	42/F	Infarction of brainstem, left cerebellar hemisphere, superior vermis, left superior cerebellar peduncle, thalamus, and left occipital cortex due to vertebral artery dissection.	Irregular, coarse, disconjugate oscillations of both eyes in all three axes, more prominent nystagmus in vertical axis.	Yes	Torticollis (mild), Right hand dystonia (mild).	Both appendicular ataxia, mild head tremor, peri-oral twiches	Memantine, gabapentin, clonazepam
5	56/M	Pontine stroke	Prominent horizontal and mild torsional nystagmus in primary gaze. No change in eccentric gaze, enucleation of the left eye.	Yes	Moderate to severe torticollis, mild retrocollis, mild shoulder elevation	Upper appendicular ataxia.	Botulinum toxin.
6	48/M	Pontine hemorrhagic stroke after AVM rupture and fall.	Horizontal, vertical, and torsional coars, irregular, disconjugate nystagmus	Yes	Moderate to severe torticollis, mild laterocollis, moderate bilateral hand dystonia, bilateral foot dystonia.		memantine