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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Chem Sci. 2015 Nov 10;7(2):989–994. doi: 10.1039/c5sc03417e

Figure 1.

Figure 1

Cellular internalization of GSGSG polymers and analogues. A) Chemical structure of peptide block copolymers. B) Flow cytometry data showing fluorescent signatures of HeLa cells treated with the polymers (m ~ 60) and their monomeric counterparts. All data are normalized to the vehicle (DPBS), which is assigned a value of 1. The R control is a block copolymer that contains a single Arg attached via a short linker at each polymer side chain of the first block (m ~ 60). “Flu” is the fluorescein end-label shown in A. C) Live-cell confocal microscopy images showing the average intensities from six consecutive 1 μm slices of HeLa cells treated with peptides and polymers (m ~ 60). Scale bars are 50 μm. In each study, the concentration of material is 2.5 μM with respect to fluorophore.