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. Author manuscript; available in PMC: 2016 Nov 2.
Published in final edited form as: Cochrane Database Syst Rev. 2015 Nov 2;11:CD003281. doi: 10.1002/14651858.CD003281.pub4
GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.