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. Author manuscript; available in PMC: 2015 Dec 22.
Published in final edited form as: Biochemistry. 2015 Jan 15;54(3):666–676. doi: 10.1021/bi501016r

Figure 6.

Figure 6

Resveratrol is not an effective inhibitor of amyloid formation by Ac 8-37-IAPP. (A) Thioflavin-T fluorescence monitored kinetic experiments for Ac 8-37-IAPP, Black; Ac 8-37-IAPP and resveratrol at a 1:1 ratio, Yellow; at a 1:2 ratio, Green; at a 1:5 ratio, Pink; at a 1:10 ratio, Red; at a 1:20 ratio, Blue. (B) An expansion of the data for Ac 8-37-IAPP with resveratrol at the 1:5, 1:10 and 1:20 ratios. TEM images of (C) Ac 8-37-IAPP alone; (D) Ac 8-37-IAPP incubated 1:5 with resveratrol and (E) Ac 8-37-IAPP incubated 1:20 with resveratrol. Samples were collected for TEM at 22 h. Samples contained 16 μM IAPP variant in pH 7.4, 20 mM Tris buffer with 1% (v/v) DMSO. Scale bars represent 100 nm.