TABLE II.

Serum Asparaginase Activity in Cycle 1 in patients receiving IV-Erwinia, 25,000 IU/m²/dose, on a Monday/Wednesday/Friday Schedule for 2 Consecutive-Weeks (6 doses =1 Cycle)

	Dose 1			Dose 2	Dose 3	Dose 4		Dose 5	Dose 6
	Pre (N =24)	5 min post (N =22)	48 hr post (N =19)	48 hr post (N =23)	72 hr post (N =21)	5 min post (N =21)	48 hr post (N =22)	48 hr post (N =24)	72 hr post (N =21)
Mean (IU/ml) ±SD		12.65 ± 3.16	0.37 ± 0.28	0.42 ± 0.36	0.088 ± 0.095	12.10 ± 3.11	0.32 ± 0.24	0.32 ± 0.23	0.089 ± 0.072
% Patients  ≥0.05 IU/ml	0	100	100	100	52	100	95	92	52
% Patients  ≥0.10 IU/ml	0	100	89	91	38	100	82	83a	43b
% Patients  ≥0.4 IU/ml	0	100	32	43	0	100	36	29	0

^aPrimary end-point.

^bSecondary end-point.