Table 1.
Asthma associations for CYP11A1 SNPs in the case-control study population.
| SNP | Allele1 | MAF2 | Call rate (%) | LD 3 bin | p-value (HWE 4) | Asthma (n=763) OR5 (95% CI) p-value |
|---|---|---|---|---|---|---|
| rs2279357 * | G/A | 0.28 | 99.7 | 5 | 0.64 | 0.85 (0.71–1.00) p=0.0554 |
| rs6161 | G/A | 0.004 | 98.6 | 1.00 | ||
| rs11632698 * | C/T | 0.40 | 99.9 | 4 | 0.42 |
0.85 (0.73–1.00) p=0.0496 |
| rs1484215 | G/A | 0.08 | 98.1 | 3 | 0.58 | 1.00 (0.76–1.32) p=0.9865 |
| rs1130841 | G/A | 0 | 98.3 | |||
| rs2073475 * | G/A | 0.14 | 98.9 | 2 | 0.26 | 0.98 (0.78–1.23) p=0.8513 |
| rs16968478 | T/C | 0.17 | 97.6 | 1.00 | 0.94 (0.77–1.14) p=0.5293 |
|
| rs9806234 # | T/C | 0.26 | 100 | 0.76 | 0.99 (0.84–1.18) p=0.9478 |
|
| rs4886595 | T/G | 0.19 | 97.3 | 0.91 |
0.77 (0.64–0.93) p=0.0079& |
|
| rs4432229 * | T/C | 0.16 | 99.9 | 1 | 0.49 |
0.80 (0.65–0.98) p=0.0351 |
Significant associations in the case control-population (N=1,454 or N=1,311*) are marked in bold letters.
The statistical analyses were performed by logistic regression modeling additive effects. To control for the experiment-wise significance level, an adjusted p-value of p=0.010 was used.
Allele: wild-type/polymorphic allele.
MAF: minor allele frequency.
LD: linkage disequilibrium.
HWE: Hardy Weinberg Equilibrium, p-value of χ2-test for deviation of HWE in controls.
Odds ratios (OR) and 95% confidence intervals (95% CI): polymorphic (minor) allele used as basis for the calculation of the effect size.
Data obtained from imputed data set.
Association between rs4886595 and asthma remains significant after correction for multiple testing with an adjusted p-value of 0.010.