Table 2.
Epistatic effects on asthma susceptibility of polymorphisms in CYP11A1 and VDR.
| Effect of | In individuals carrying | Reference allele1 | Odds ratio (95% CI) | p-value |
|---|---|---|---|---|
|
CYP11A1 rs4886595 |
G | 0.77 (0.64–0.93) | 0.0079 | |
|
CYP11A1 rs4432229 |
C | 0.80 (0.65–0.98) | 0.0351 | |
|
VDR rs2107301 |
A | 0.76 (0.64–0.89) | 0.0010 | |
|
CYP11A1 rs4886595 |
VDR rs2107301 GG (n=660) | G | 0.71 (0.54–0.94) | 0.0176 |
|
CYP11A1 rs4886595 |
VDR rs2107301 GA+AA (n=608) | G | 0.82 (0.62–1.10) | 0.1894 |
|
VDR rs2107301 |
CYP11A1 rs4886595 TT (n=835) | A | 0.75 (0.60–0.93) | 0.0082 |
|
VDR rs2107301 |
CYP11A1 rs4886595 TG+GG (n=433) | A | 0.73 (0.54–0.98) | 0.0372 |
|
CYP11A1 rs4432229 |
VDR rs2107301 GG (n=678) | C | 0.73 (0.54–0.98) | 0.0354 |
|
CYP11A1 rs4432229 |
VDR rs2107301 GA+AA (n=624) | C | 0.90 (0.67–1.21) | 0.4785 |
|
VDR rs2107301 |
CYP11A1 rs4432229 TT (n=928) | A | 0.75 (0.61–0.91) | 0.0051 |
|
VDR rs2107301 |
CYP11A1 rs4432229 TC+CC (n=374) | A | 0.76 (0.56–1.05) | 0.0970 |
The entire case-control study population was stratified for the CYP11A1 polymorphisms rs4886595, and rs4432229 and rs2107301 (VDR) to investigate the SNP effect on asthma susceptibility of one SNP in relation to the other polymorphism. The statistical analyses were performed by logistic regression modeling additive effects.
1
Allele: polymorphic (minor) allele was used as basis for the calculation of the effect size.