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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Mol Pharmacol. 2008 Oct 15;75(1):208–217. doi: 10.1124/mol.108.048314

Figure 8.

Figure 8

YC-1 enhances cytokine-mediated NO synthesis and iNOS protein expression in a soluble guanylate cyclase (sGC)-dependent manner. A. Effect of the sGC inhibitor, ODQ, (30 μM) on the stimulatory effect of YC-1 (30μM) on nitrite production following the treatment of cells with a cytokine mixture (CM) consisting of interleukin-1β (5ng/ml) and tumor necrosis factor-α (20ng/ml) for 24 hours. B. Effect of the sGC inhibitor, ODQ, (30 μM) on the stimulatory effect of YC-1 (30μM) on iNOS protein expression following the treatment of cells with a CM consisting of interleukin-1β (5ng/ml) and tumor necrosis factor-α (20ng/ml) for 24 hours. iNOS protein is expressed in arbitrary units (a.u.). Results are means ± SEM of 4-6 experiments. *Statistically significant effect of CM. †Statistically significant effect of YC-1.