. Author manuscript; available in PMC: 2009 Oct 1.

Published in final edited form as: Ann Noninvasive Electrocardiol. 2008 Oct;13(4):327–331. doi: 10.1111/j.1542-474X.2008.00250.x

Table 2.

Cox model: Factors Associated with Risk for a 1^st LQTS-related Cardiac Event in 641 Patients Older than 40 years of Age with QTc ≥ 450ms

Variable	Hazard Ratio	95% Confidence Interval	p Value
Time-dependent coronary disease	2.24	1.23 – 4.07	0.008
QTc ≥ 500ms	1.22	0.83 – 1.81	0.31
Females	1.19	0.77 – 1.84	0.44
Prior Syncope	3.72	2.44 – 5.67	< 0.0001
Time-dependent beta-blockers	0.76	0.48 – 1.20	0.24

Note: QTc≥500ms, female gender, and time-dependent beta-blockers were forced into the model. Neither diabetes mellitus or hypertension made a significant contribution to the model. Time-dependent beta-blockers utilized decade stratification of patients by date of birth (see Methods).