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. Author manuscript; available in PMC: 2016 Jan 2.
Published in final edited form as: J Alzheimers Dis. 2015 Oct 1;48(3):647–665. doi: 10.3233/JAD-150398

Figure 5. Dysregulation of long intergenic non-coding RNAs in LOAD.

Figure 5

A) Schematic representation of the loci expressing the newly discovered lincRNAs AD-linc1 and AD-linc2 (in black).

B) commercially available RNA from different human tissues. On the Y axe is depicted the expression of the analyzed gene relative to the housekeeping gene β-ACTIN.

C) qRT-PCR analysis of AD-linc1 and AD-linc2 expression in RNA extracted from hNSCs fractionated in different cellular compartments: cytosol (Cyto), nucleoplasm (Nuc) and chromatin (Chr).

qRT-PCR expression analysis AD-linc1 (D) and AD-linc2 (E) in post mortem brain tissues from four different regions of LOAD and age-matched control. Cer=Cerebellum (24 patients, 20 controls), SFG=Superior frontal Gyrus (17 patients, 18 controls), Ectx=Entorhinal cortex (8 patients, 9 controls), Hipp=Hippocampus (12 patients, 10 controls). On the Y axe is depicted the expression of the analyzed gene relative to the housekeeping gene PGK1. Gene expression is normalized to CTRL.

Error bars are S.E.M.; * denotes p values <0.05; ** denotes p values <0.01.