Skip to main content
. Author manuscript; available in PMC: 2016 Jan 2.
Published in final edited form as: J Alzheimers Dis. 2015 Oct 1;48(3):647–665. doi: 10.3233/JAD-150398

Table 4. Pathway analysis.

The integrated knowledge-based platform GeneGo was used to perform pathway analysis of differentially expressed protein coding genes in LOAD. The most enriched process networks are listed here.

Networks pValue Min FDR Network Objects from
Active Data
Signal
transduction_Neuropeptide
signaling pathways 		8.916E-04 5.573E-02 EDNRA (Galpha(q)-specific peptide
GPCRs), GRP (GRP precursor), MCHR2
PRKAR1B (PKA-reg (cAMP-dependent)),
PKD1L2, TAC1 (Substance P)
Neurophysiological
process_Transmission of
nerve impulse 		1.230E-03 5.573E-02 SLC5A7 (CHT1), ADRB3 (Galpha(i)-
specific amine GPCRs, Galpha(s)-specific
amine GPCRs), HTR3B, SCN11A
(NAV1.9), PRKAR1B (PKA-reg (cAMP-
dependent)), TH (TY3H)
Muscle contraction 1.691E-03 5.573E-02 EDNRA (Galpha(q)-specific peptide
GPCRs), ADRA1D (Galpha(q)-specific
amine GPCRs), GUCA1C (GCAP),
MYBPC1 (MYPS), CHRNA3 (nAChR
alpha), TNNT2 (Troponin T, cardiac)
Development_Blood vessel
morphogenesis 		1.956E-03 5.573E-02 ADRB3 (Beta-3 adrenergic receptor,
Galpha(i)-specific amine GPCRs, Galpha(s)-
specific amine GPCRs), BMP4, EDNRA
(EDNRA, EDNRB, Galpha(q)-specific
peptide GPCRs), FGF10