Fig. 4.

Inflammation regulated PSC generates larger spheres, as well as more tubule-like spheres. (A) H&E stained sections showed solid spheres (upper) and tubule-like spheres (lower) in naïve and inflamed groups. (Scale bar: 100 μm) (B) A bar graph shows diameters of two types of spheres. (n=46 in naïve solid spheres; n=12 in naïve tubule-like spheres; n=17 in inflamed solid spheres; n=12 in inflamed tubule-like spheres; error bar=SE; determinations were combined from 3 independent experiments.) (C) A scanning electron microscope (SEM) image shows weighing of an inflamed prostate sphere. The resonator comprised a sensor and a reference cantilever beam. (D) The average density of inflamed spheres (blue bars and curve) is 1.29 g/cm³; naïve spheres (red bars and curve) is 1.1 g/cm³. Specific values of density on x-axis correspond to the actual numbers of spheres on y-axis. (n=42 in naïve group; n=37 in inflamed group; Student’s t-test, p<0.0001)