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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Cell Mol Gastroenterol Hepatol. 2016 Mar;2(2):222–237. doi: 10.1016/j.jcmgh.2015.12.001

Fig. 7. In vivo imaging in CPC;Apc mouse colon.

Fig. 7

White light images show A,B) a spontaneous polyp (arrow) and C) normal appearing mucosa. NIR fluorescence images after topical administration of RTS*-Cy5.5 shows D) increased intensity from polyp (arrow) in A), E) presence of flat lesion above polyp in B), and F) flat lesions not apparent on white light image in C). Representative individual images were extracted from videos recorded at 15 frames per second that showed minimum motion artifact and absence of debris (stool, mucus). Histology (H&E) of G) polyp in A) and H) flat lesion in B) shows features of low-grade dysplasia. I) From n = 5 mice, RTS*-Cy5.5 had a higher mean (±std) T/B ratio than SPT*-Cy5.5 for n=8 polyps (2.3±0.3 and 1.2±0.2, respectively, P=3×10−4 by paired t-test) and n = 9 flat lesions (1.9±0.5 and 1.1±0.2, respectively, P=8×10−3 by paired t-test).