Fig. 7.
QSM of early-stage PD illustrates the regions of deep brain nuclei (A–B). CN, the head of caudate nucleus; PUT, putamen; GP, globus pallidus; SN, substantia nigra; RN, red nucleus. C. Scatter plots and regression lines show the significant relationship between susceptibility values in bilateral SN and clinical measures in early-stage PD. Correlations are partialed for age. The susceptibility value of ipsilateral SN is positively correlated with disease duration (upper-left: r = 0.391, P = 0.0094) and UPDRS-III score (bottom-left: r = 0.386, P = 0.0105) in PD. The susceptibility value in SN contralateral to the most affected side in PD patients is positively correlated with disease duration (upper-right: r = 0.347, P = 0.0226) and UPDRS-III score (bottom-right: r = 0.368, P = 0.0152). Figure reproduced from He et al. (76) with permission.