TABLE III.
Results of the general linear model [Eq. (3)] analysis, where processing speed served as the dependent variable and regional WM to average GM CBF ratios and FA values for the ten WM tracts served as predictor variables
| Processing Speed | Genu | Body | Splenium | IC | CR | TR | EC | Cing | SLF | FO |
|---|---|---|---|---|---|---|---|---|---|---|
| Patients | ||||||||||
| β Ratio CBFwm to CBFgm (P-value) | 212.83 ± 67.55 (3.1 × 10−3) | 158.94 ± 54.93 (6.2 × 10−3) | 159.57 ± 59.17 (0.01) | 31.08 ± 58.25 (0.60) | 216.09 ± 67.10 (2.6 × 10−3) | 68.86 ± 63.13 (0.28) | 41.93 ± 57.27 (0.47) | 91.20 ± 33.08 (8.8 × 10−3) | 91.43 ± 49.15 (0.07) | 79.10 ± 45.35 (0.09) |
| BFA (P-value) | −20.80 ± 46.65 (0.66) | 1.20 ± 40.65 (0.98) | −65.33 ± 52.41 (0.22) | 101.02 ± 118.31 (0.40) | 50.59 ± 83.15 (0.55) | 87.39 ± 68.92 (0.21) | 97.09 ± 117.51 (0.41) | −15.23 ± 58.31 (0.80) | 79.47 ± 88.23 (0.37) | 99.55 ± 73.64 (0.18) |
| r2 | 18% | 22% | 11% | 0.01% | 26% | 7% | 0.5% | 14% | 11% | 8% |
| F (P-value) | 5.53 (7.7 × 10−3) | 6.73 (3.1 × 10−3) | 3.65 (0.04) | 1.00 (0.38) | 8.03 (1.2 × 10−3) | 2.62 (0.09) | 1.12 (0.34) | 4.21 (0.02) | 3.63 (0.04) | 2.7 (0.08) |
| Controls | ||||||||||
| β Ratio CBFwm to CBFgm (P-value) | 150.27 ± 43.11 (8.2 × 10−4) | 102.11 ± 33.39 (3.1 × 10−3) | 124.80 ± 44.24 (0.01) | 135.99 ± 46.41 (4.5 × 10−3) | 124.29 ± 42.98 (0.01) | 88.95 ± 44.78 (0.05) | 105.69 ± 44.23 (0.02) | 75.32 ± 20.58 (4.7 × 10−4) | 138.45 ± 42.32 (1.6 × 10−3) | 108.47 ± 31.56 (9.7 × 10−4) |
| βFA (P-value) | 137.10 ± 36.35 (3.2 × 10−4) | 108.46 ± 38.65 (.01) | 238.40 ± 70.38 (1.1 × 10−3) | 131.35 ± 72.71 (0.07) | 256.52 ± 67.85 (3.1 × 10−4) | 190.60 ± 54.57 (8.1 × 10−4) | 232.44 ± 78.61 (4.2 × 10−3) | 107.96 ± 50.90 (0.04) | 167.68 ± 68.97 (0.02) | 116.12 ± 57.64 (0.05) |
| r2 | 26% | 18% | 19% | 11% | 19% | 18% | 13% | 18% | 16% | 15% |
| F (P-value) | 14.47 (4.9 × 10−6) | 9.58 (2.0 × 10−4) | 10.19 (1.2 × 10−4) | 5.65 (0.01) | 9.93 (1.5 × 10−4) | 9.52 (2.1 × 10−4) | 6.76 (2.0 × 10−3) | 9.24 (2.6 × 10−4) | 8.14 (6.4 × 10−4) | 7.69 (9.2 × 10−4) |
This modeling was performed for patient and control groups.
The WM tracts were abbreviated as follows: IC, internal capsule; CR, corona radiata; TR, thalamic radiation; EC, external capsule; Cing, cingulate; SLF, superior longitudinal fasciculus; FO, superior and inferior fronto-occipital fasciculi.