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. Author manuscript; available in PMC: 2016 Oct 19.
Published in final edited form as: Stat Med. 2016 Jan 5;35(14):2467–2478. doi: 10.1002/sim.6844

Table I.

Low-Event-Rate Meta-Analyses Published in JAMA between 2007 and 2013

Reference # Multiple analyses.1 and .2 M Endpoint Lead Author
13 27 Suicide ideation/Attempt Bridge (2007)
14 63 Antibiotic-Associated Diarrhea Hempel (2012)
15 15 Risk of Low Birth Weight Kayentao (2013)
16 15 Venous Thromboembolism Nalluri (2008)
17.1 8 Lung Injury Neto (2012)
17.2 9 Mortality Neto (2012)
18.1 8 Cardiovascular Deaths Nguyen (2011)
18.2 11 Prostate Cancer-Specific Mortality Nguyen (2011)
19.1 21 Incident Pancreatitis in 21 Large Statin Trials Preiss (2012)
19.2 7 Incident Pancreatitis in 7 Large Fibrate Trials Preiss (2012)
20 16 Fatal Adverse Events Ranpura (2011)
21 17 All-Cause Mortality Rizos (2012)
22.1 17 Major Cardiovascular Events-Inhaled Anticholinergics Singh (2008)
22.2 5 Major Cardiovascular Events Long term Inhaled Anticholinergics Singh (2008)
23.1 5 Major Cardiovascular Events Udell (2013)
23.2 5 Cardiovascular Mortality Udell (2013)
24 25 In Hospital Mortality Wiener (2008)
25 35 Mortality Zarychanski (2013)

M=Number of Studies in Analysis

Studies where DL and SGS differ substantially are highlighted.