Table 1.
Plasma Serotonin |
Clinical Outcome |
Remission at 4 wks |
Remission at 8 wks |
Response at 4 wks |
Response at 8 wks |
% change at 4wks |
% change at 8wks |
---|---|---|---|---|---|---|---|
Baseline |
p = 0.012
OR = 1.41 |
p = 0.028
OR = 1.31 |
p = 0.007
OR = 1.40 |
p = 0.047
OR = 1.30 |
p = 0.015
r = −0.14 |
p = 0.019
−0.14 |
|
Change after 4
weeks |
p = 0.011
OR = 1.40 |
p = 0.041
OR = 1.27 |
p = 0.026
OR = 1.31 |
p = 0.060
OR = 1.27 |
p = 0.021
r = −0.13 |
p = 0.024
r = −0.13 |
|
Change after 8
weeks |
p = 0.069 OR =1.27 |
p = 0.147 OR = 1.19 |
p = 0.037
OR = 1.29 |
p = 0.130 OR = 1.21 |
p = 0.041
r = −0.12 |
p = 0.06
r = −0.11 |
Plasma serotonin concentrations at baseline and decreases in plasma serotonin concentrations after four weeks of SSRI treatment were nominally associated with remission, response, and percent change in QIDS-C16 score. The decrease in plasma serotonin between baseline and eight weeks of SSRI treatment was associated only with the response at four weeks and percent change in QIDS-C16 at four weeks. OR > 1 indicates improvement (associated with higher baseline and larger changes in plasma serotonin concentrations) and the negative r values indicate a decrease in QIDS-C16 scores, ie: improvement. P-values < 0.05 have been bolded.