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. Author manuscript; available in PMC: 2016 Sep 10.
Published in final edited form as: Nature. 2016 Feb 8;531(7592):114–117. doi: 10.1038/nature16988

Figure 3. Pre-fusion structure of the coronavirus fusion machinery.

Figure 3

a-b, Topology and ribbon diagrams showing the structural similarity between coronavirus MHV S2 (starting at residue 755, a) and paramyxovirus RSV F (PDB 5C6B, b). For clarity, only part of RSV F is shown with conserved secondary structural elements colored identically as for MHV S2. #: motifs participating to the post-fusion HR1 coiled-coil. FP: fusion peptide. c-d, Two different views of the MHV S trimer (from the side (c) and top, looking toward the host cell membrane, d) highlighting how S1 (ribbon diagram and semi-transparent surface) wraps around the S2 fusion machinery (ribbon diagram) to stabilize it.