Table 4.

Characteristics of excluded studies [ordered by study ID]

Study	Reason for exclusion
Guymer 2014	Non-randomised study assessing a novel, ultra-low energy nanosecond laser (retinal rejuvenation therapy) to slow progression of early age-related macular degeneration. Drusen reduction was achieved in 44% of treated eyes and 22% of untreated fellow eyes
Huang 2011	Paired controlled study (10 participants): 1 eye randomly assigned to laser, the fellow eye to control. However, authors reported that participants could have chosen which eye had to receive laser, so unclear whether randomisation was maintained
Sarks 1999	Comparative study but no randomisation
Sigelman 1991	Case report