Table 1. Demographic and Disease Characteristics of Subjects with and Without Deep Brain Stimulation. Values reported are mean ± SD.
Variable | DBS Group (n = 100) | Non-DBS Group (n = 684) | P |
---|---|---|---|
Age of onset | 40.3 ± 7.1 | 41.7 ± 6.9 | 0.06 |
Age at baseline evaluation | 56.7 ± 7.9 | 51.6 ± 9.1 | <0.0001 |
Disease duration, y | 16.5 ± 6.8 | 9.9 ± 7.8 | <0.0001 |
AJ ancestry, % of subjects | 15.0 | 15.8 | 0.81 |
Ethnicity, %a | |||
White | 83.0 | 82.0 | 0.51 |
African-American | 0.0 | 15.0 | |
Hispanic | 13.0 | 12.3 | |
Other | 4.0 | 3.51 | |
UPDRS-IIIb | 24.8 13.1 | 20.3 11.7 | 0.002 |
MMSEc | 28.8 ± 1.9 | 28.9 ± 2.1 | 0.22 |
Prior history of dyskinesia, % of subjectsd | 78.3 | 37.9 | <0.0001 |
Prevalence of mutation carriers, %e | 26.5 | 16.8 | 0.019 |
Non-DBS, n = 683.
DBS, n = 89; non-DBS, n = 641.
DBS, n = 97; non-DBS, n = 664.
DBS, n = 83; non-DBS, n = 475.
DBS, n = 98; non-DBS, n = 661.
SD, standard deviation; DBS, deep brain stimulation; AJ, Ashkenazi Jewish; MMSE, Mini Mental Status Examination; UPDRS-III, the motor subsection of the Unified Parkinson's Disease Rating Scale.