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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Antiviral Res. 2015 Feb 7;116:76–84. doi: 10.1016/j.antiviral.2015.01.011

Figure 2. Inhibition of serine and/or cysteine proteases in cells transfected with, or endogenously expressing, TMPRSS2.

Figure 2

293T-CD13 cells transiently expressing TMPRSS2 (a) or Caco2 cells (B) were pretreated with serially diluted compound K11777, or a combination of serially diluted K11777 and camostat at two different concentrations (1µM or 10µM), followed by incubation with infectivity-normalized pseudoviruses in the presence of the inhibitors. The cells were then cultured at 37°C/5% CO2 for two days and luciferase expression was measured. (a) Simultaneous treatment with both K11777 and camostat for 229E-S, EBOV or VSV-G pseudovirus infection. (b) Enhanced inhibition by a combination of K11777 and camostat for 229E-S mediated viral entry using Caco2 cells.