Table 2.
Contrast Map and Brain Region | Cluster Size | MNI Coordinates (x y z) | Analysis (z) |
---|---|---|---|
Left Amygdala ALLO > Placebo | |||
Left Superior Frontal Gyrus | 2687 | −9 −28 76 | 3.84 |
Superior Medial Frontal Gyrus (dmPFC) | 196 | −12 41 37 | 2.82 |
Precuneus | 199 | −9 −40 55 | 2.86 |
Right Amygdala ALLO > Placebo | |||
Left Middle Temporal Gyrus | 1522 | −45 −19 −11 | 3.91 |
Left Hippocampus | 18 | −36 −16 −11 | 2.84 |
Left Amygdala DHEA > Placebo | |||
Left Supramarginal Gyrus | 2038 | −66 2 7 | 3.62 |
Left Insula | 165 | −36 −1 −8 | 2.81 |
Left Amygdala | 8 | −24 −7 −14 | 2.40 |
Left Amygdala DHEA > ALLO | |||
Medial Frontal Gyrus | 2049 | −15 50 10 | 3.88 |
dmPFC | 396 | −12 53 10 | 3.58 |
Cluster-level significance set at p < .05, whole brain corrected for multiple comparisons. Within each significant cluster, Z-score and associated a priori region are noted along with MNI atlas coordinates of peaks, in bold. ALLO, allopregnanolone; dmPFC, dorsal medial prefrontal cortex; MNI, Montreal Neurologic Institute.