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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Nanomedicine (Lond). 2015 Jul;10(12):1881–1897. doi: 10.2217/nnm.15.37

Figure 1. Stoichiometry of viral DNA packaging motor.

Figure 1

(A) Illustration of Phi29 DNA packaging motor composed of one copy of genomic DNA that revolves through the channel wall (left panel), six copies of pRNA, six copies of ATPase gp16 and a connector channel. (B) Yang Hui Triangle. (C) Illustration of Z = 6 and K = 1, drug targeting anyone subunit of the complex will block its activity. (D) Atomic force microscopy image of hexameric re-engineered pRNA rings. (E) 3D structure of hexameric pRNA ring top view and side view from the crystal structure of 3WJ (PDB ID: pRNA 3WJ, 4KZ2). (F) A crystal hexameric structure of AAA+ Protein CbbX withtop view and side view [59] (PDB ID: CbbX, 3Zuh[60]). (G) Structure of the hexameric AAA+ molecular machine ClpC with adaptor protein MecA [61] (PDB ID: MecA-ClpC, 3PXG).

AAA+: ATPases associated with diverse cellular activities.