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. Author manuscript; available in PMC: 2016 Feb 17.
Published in final edited form as: JCI Insight. 2016 Jan 21;1(1):e85293. doi: 10.1172/jci.insight.85293

Figure 2. HLA-DR blockade reduces CD8+ T cell infiltration into and CTL development within implanted allogeneic vessel segments in vivo.

Figure 2

(A and B) Anti–HLA-DRα F(ab)′2 fragment significantly (n = 6 per group) reduces total intimal T cell infiltration as detected by immunofluorescence (scale bar: 20 μm) (A) and CD8+ T cell–associated transcripts of cytokines and CTL effector molecules in rejected artery grafts at 21 days (B) as detected by qPCR normalized to either total mRNA or T cell–specific mRNA as indicated on the y axis. Arrows indicate infiltrating intimal CD45RO+ T cells. *P < 0.05, 2-tailed Student's t test. CTL, cytotoxic T cell.