Table 3. DEPs associated with the most significantly enriched canonical pathways.

Name of canonical pathways	Associated DEPs	Overlap Ratio§	P-value*
LXR/RXR activation	AHSG, APOA4, APOB, C4A/C4B GC,HPR,ITIH4,PON1, RBP4	9/121 (7.4%)	1.4×10-15
FXR/RXR activation	AHSG,APOA4,APOB,C4A/C4B,GC,HPR ITIH4,PON1,RBP4	9/125 (7.2%)	1.9×10-15
Acute Phase Response Signaling	AHSG,C4A/C4B,CFB,CRP,HRG,ITIH2, ITIH4,RBP4,SERPING1	9/168 (5.4%)	2.9×10-14
Complement system	C4A/C4B,CFB,SERPING1	4/36 (11.1%)	4.6×10-08
Atherosclerosis signaling	APOA4,APOB,PON1, RBP4	4/121 (3.3%)	6.3×10-06

^§Numerator of ratio represents the number of DEPs in our data set that maps to the canonical pathway; the denominator represents the total number of molecules/proteins that map to the pathway

^*P-value obtained by Fisher's exact test