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. Author manuscript; available in PMC: 2016 Jun 22.
Published in final edited form as: Eur J Immunol. 2015 Dec 2;46(2):455–463. doi: 10.1002/eji.201545537

Figure 4.

Figure 4

TSLP secretion requires independent activation of ER stress and IL-1 dependent signalling. (A) mDC were pre-incubated for one hour with or without IRE1α or PERK inhibitors and were then stimulated with CUR, MP or C. albicans for 24 hours (n=12). (B) mDC were pre-incubated for one hour with or without IRE1α or PERK inhibitors and were then stimulated with CUR, MP or C. albicans with or without recombinant IL-1β for 24 hours (n=9). TSLP and IL-1β were measured in 24 hour cell culture supernatants by ELISA. Cumulative data are shown as mean ± SEM. Statistical significance was calculated using oneway ANOVA with Bonferroni post-tests (*** p=0.001, ** p=0.01, * p=0.05).