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. Author manuscript; available in PMC: 2016 Feb 22.
Published in final edited form as: Environ Epigenet. 2015 Sep 11;1(1):dvv003. doi: 10.1093/eep/dvv003

Table 4.

Mediation analysis: total, direct, and indirect effect

Newborns 9-Year olds
PC1-1 PC1-2 PC1-1
Estimate (95% CI) P Estimate (95% CI) P Estimate (95% CI) P
Total effect 16.3(−22.1, −10.5) <0.0005 −15.6(−21.5, −9.7) <0.0005 −30.6(−42.9, −18.3) <0.0005
Natural direct effect −23.2(−30.8, −15.6) <0.0005 −19.1(−26.3, −11.9) <0.0005 −15.6(−35.3,4.19) 0.123
NIE 6.9(1.5,12.4) 0.013 3.5(−1.8,8.9) 0.195 −15.0(−30.9,0.83) 0.063

CI, confidence interval.