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. Author manuscript; available in PMC: 2016 Mar 29.
Published in final edited form as: JCI Insight. 2016 Feb 25;1(2):e85562. doi: 10.1172/jci.insight.85562

Figure 3. Application of the pan–human polyomavirus survey to known HPyV-associated diseases.

Figure 3

Formalin-fixed paraffin-embedded tissue sections from JC virus–related (JCV-related) progressive multifocal leukoencephalopathy (PML), Merkel cell polyomavirus–positive (MCV-positive) or -negative Merkel cell carcinoma (MCC), human polyomavirus 7–related (HPyV7-related) skin rash lesion, and trichodysplasia-spinulosa virus-related (TSV-related) trichodysplasia spinulosa (TS) were stained with triple antibody combination overnight and counterstained with hematoxylin. JCV T antigen is detected mostly in oligodendrocytes. Nuclear MCV T antigen is detected in the whole tumor section. HPyV7 T antigen is expressed in the nuclei and cytoplasm of the hyperplastic epithelium. TSV T antigen is expressed in the affected hair follicle cells. Original magnification, ×10 (A); ×40 (B).