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Mean (±SEM) (A) and individual subject (B) molar ratios of (M + 5) to (M + 0) for 5-methyltetrahydrofolate in plasma after initiation of disintegration of enteric-coated caplets containing 855 nmol [13C5]5-formyltetrahydrofolate. The change in the mean molar ratio was significant (P = 0.0250; repeated-measures ANOVA). No [13C5]5-formyltetrahydrofolate was observed in the plasma of any subject.
