TABLE 1.
Subject characteristics1
| Value | Range | |
|---|---|---|
| Sex (F/M) (n) | 3/6 | – |
| Age (y) | 25 ± 12 | 22–26 |
| Weight (kg) | 73.2 ± 17.2 | 47.8–103.6 |
| BMI (kg/m2) | 24.6 ± 3.6 | 18.8–29.9 |
| Plasma volume (L)3 | 2.91 ± 0.7 | 1.87–4.07 |
| MTHFR 677C>T | ||
| CC | 5 | – |
| CT | 4 | – |
| Red blood cell folate (nmol/L) | 1108 ± 437 | 604–1988 |
| Total plasma folate (nmol/L) | 41.7 ± 17.7 | 14.9–68.5 |
| Vitamin B-12 (pmol/L) | 331 ± 188 | 151–583 |
| Pyridoxal-5-phosphate (nmol/L)4 | 53 ± 17 | 34–82 |
| Ethnicity (n) | ||
| Middle Eastern | 1 | – |
| White | 5 | – |
| Chinese | 2 | – |
| South Asian | 1 | – |
| Dietary intake of folate during blood sampling (μg DFE) | ||
| After intravenous injection | 12 ± 1.2 | 7.3–25 |
| After caplet ingestion | ||
| 0–14 h | 47.9 ± 8.0 | 2.47–65.9 |
| 15–24 h | 48.0 ± 19.4 | 0–162.3 |
| 25–48 h | 327.3 ± 74.9 | 26.6–677.2 |
1
n = 9 unless otherwise indicated. DFE, dietary folate equivalent.
2
Mean ± SD (all such values).
3
Whole blood volumes were calculated by using an estimate of 66.5 mL/kg for women and 75 mL/kg for men (23). The plasma volume was calculated from the estimated whole blood volume by using an adjustment for the packed cell volume.
4
n = 8.