TABLE 2.

Pharmacokinetic data from subjects (n = 6) who exhibited a linear plasma folate response after caplet ingestion of 855 nmol [¹³C₅]5-formyltetrahydrofolate¹

	Plasma volume	Sex	tdelay	Cmax	tmax	Rate of appearance	Caplet disintegration
							Initiation location	Completion location
	L		h	nmol	h	nmol/h
Subject
A	2.21	F	5	3.7	6.0	0.72	ICJ	Cecum
B	4.07	M	8	4.0	10.0	0.37	Cecum	Ascending
C	1.87	F	4	1.6	5.5	0.31	ICJ	Ascending
D	3.54	M	6	3.7	7.1	0.33	Cecum	Ascending
E	2.77	M	6	0.5	10.1	0.05	Cecum	ND2
F	2.38	F	7	2.0	10.0	0.21	ICJ	Ascending
Mean ± SEM	2.9 ± 0.3	–	6.6 ± 1.0	2.6 ± 0.6	8.7 ± 0.9	0.33 ± 0.09	–	–

¹Rate of appearance was determined from the ascending slope for the concentration of labeled [¹³C₅]5-methyltetrahydrofolate in the plasma of 6 subjects with complete caplet disintegration. C_max, maximal concentration; ICJ, ileocecal junction; ND, not detected; t_delay, time lag before detection of [¹³C₅]5-methyltetrahyrofolate in plasma after caplet ingestion (baseline) in 6 subjects; t_max, time of maximal concentration.

²Last image was taken in the transverse colon.