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. Author manuscript; available in PMC: 2016 Apr 6.
Published in final edited form as: Am J Clin Nutr. 2014 Sep 3;100(5):1278–1286. doi: 10.3945/ajcn.114.091785

TABLE 3.

Pharmacokinetic data after intravenous injection of 214 nmol [13C5]5-formyltetrahydrofolate1

5-formyltetrahydrofolate
5-methyltetrahydrofolate
Cmax t1/2 Cmax Rate of appearance
nmol h nmol nmol/h
Subject
A 14.1 0.376 10.0   4.0 ± 1.0
B   7.5 0.279 5.0 4.2 ± 1.8
C 10.9 0.315 6.0 3.1 ± 0.8
D 15.2 0.300 5.8 5.3 ± 1.6
E 20.0 0.262 6.8 6.4 ± 1.1
F 10.2 0.330 6.6 6.2 ± 1.6
G 20.3 0.305 10.2   14.5 ± 7.7
H   7.1 0.244 3.1 2.9 ± 0.6
I 15.9 0.593 7.8 5.6 ± 0.2
Mean ± SEM 13.5 ± 1.6 0.3 ± 0.03 6.8 ± 0.8 5.8 ± 1.2
1

Rate of appearance was determined from the ascending slope over time of the concentration of labeled [13C5]5-methyltetrahydrofolate in plasma (n = 9). Cmax, maximal concentration; t1/2, apparent plasma half-life.