Table 4.

Change in perfusion of brain tumors by tumor volume change Mean ± SD of change in perfusion variables from baseline for each tumor region at first recheck and second recheck for dogs with increased tumor size at first recheck versus those with decreased or stable tumor size. Significant changes are indicated with an asterisk.

Tumor Region	Variable	Change from baseline	First Recheck Tumor Volume Increased from Baseline
			No	Yes	p	FDR
Whole Tumor	Blood flow (ml/100g/min)	First recheck	−0.91±2.10	−1.36±1.91	0.70	0.90
		Second recheck	−0.98±1.82	−4.94±0.41	0.012	0.10
	Blood volume (m/100g)	First recheck	−1.05±3.00	−0.69±3.19	0.83	0.90
		Second recheck	−2.27±1.68	−1.85±3.59	0.78	0.90
	Permeability (ml/100g/min)	First recheck	−5.96±18.35	−2.50±21.17	0.73	0.90
		Second recheck	−10.58±25.22	−17.00±4.67	0.73	0.90
Tumor Center	Blood flow (ml/100g/min)	First recheck	−1.18±1.92	−1.99±2.61	0.51	0.90
		Second recheck	−1.20±1.34	−6.16±0.43	<0.001	0.009*
	Blood volume (ml/100g)	First recheck	−1.18±1.92	−1.99±2.61	1.0	1.0
		Second recheck	−2.22±2.01	−1.39±1.78	0.60	0.890
	Permeability (ml/100g/min)	First recheck	−7.91±29.29	18.92±46.98	0.17	0.78
		Second recheck	−19.12±34.38	−14.33±42.83	0.85	0.90
Periphery	Blood flow (ml/100g/min)	First recheck	−1.16±1.94	0.97±4.63	0.51	0.90
		Second recheck	0.28±2.98	−5.35±1.19	0.029	0.17
	Blood volume (ml/100g)	First recheck	−1.14±3.16	−0.39±4.54	0.72	0.90
		Second recheck	−1.72±3.18	−2.71±3.91	0.70	0.90
	Permeability (ml/100g/min)	First recheck	−11.74±29.67	22.41±60.99	0.26	0.90
		Second recheck	−7.00±30.58	−12.91±15.35	0.80	0.90